Poster Session

A personalized approach to proteogenomic characterization of MHC loss across cancers
Michael B. Mumphrey, Noshad Hosseini, Abhijit Parolia, Jie Geng, Weiping Zou, Malini Raghavan, Arul Chinnaiyan, and Marcin Cieslik

Characterizing tandem repeats with targeted, long-read sequencing
Camille Mumm, Kinsey Van Deynze, Preston Parana, Jessica A. Switzenberg, Connor Maltby, Ryan E. Mills, Peter K. Todd, and Alan P. Boyle

Clinical Validation and Extension of Neuropsychiatric Pharmacogenomics (PGx) Assays Using a Novel Machine Learning/AI Platform
Brian Athey, Qingzhi Liu, Alex Ade, Monica Holmes, Lars Fritsche, and Veerabhadran Baladandayuthapani

Deciphering Multi-way Interactions in the Human Genome
Joshua Pickard, Cooper Stansbury, and Indika Rajapakse

Decoding the cell-type specific regulatory mechanisms of MHC expression across healthy tissues and cancers
Mahnoor Naseer Gondal, Marcin Cieslik, and Arul M. Chinnaiyan

Detection of somatic variation in human neurons using long-read sequencing approaches
Weichen Zhou, Camille Mumm, Jessica A. Switzenberg, Peter K. Todd, Michael J. McConnell, Alan P. Boyle, and Ryan E. Mills

Distribution-free deconvolution of spatial transcriptomic data using heterogeneous single-cell datasets
J. Sodicoff, A. Kriebel, and J. Welch

Genetic effects on chromatin accessibility and nucleosome positioning using snATAC data across 284 skeletal muscle biopsies
Xiaoou Wang, Catherine C. Robertson, Arushi Varshney, Nandini Manickam, Peter Orchard, Markku Laakso, Jaakko Tuomilehto , Timo A. Lakka, Karen L. Mohlke, Michael Boehnke, Laura Scott, Heikki A. Koistinen, Francis S. Collins, Stephen C.J. Parker

Girls Who Code at U-M DCMB: Teaching Python for Data Science
Kelly L. Sovacool, April Kriebel, Hayley Falk, Audrey C. Drotos, Katherine L. Furman, Sarah E. Haynes, Negar Farzaneh, Vy Kim Nguyen, Logan A. Walker, Rucheng Diao, Morgan Oneka, Alana Woloshin, Gabrielle A. Dotson, Lucy Meng, Stephanie N. Thiede, Marlena Duda, Zena Lapp, and Brooke N. Wolford

Identification and characterization of HPV genomic integrations in head and neck squamous cell carcinomas
Wenjin Gu

Identifying mechanisms of radioresistance in breast cancer
Breanna McBean, Anna Michmerhuizen, Kari Wilder, Romans, Benjamin Chandler, Lynn Lerner, Meilan Liu, Alan Boyle, and Corey Speers

Incorporating pharmacometabolic measurements to improve pharmacogenomic testing and support genome-guided medication prescribing and Treatment
Monica Holmes, Alex Ade, Lars Fritsche, Qingzhi Liu, Veerabhadra Baladandayuthapani, and Brian Athey

Integrating single cell and spatial transcriptomics define gene signature for pancreatic ductal adenocarcinoma pre-neoplastic lesion
Ahmed M. Elhossiny, Eileen Carpenter, Padma Kadiyala, Yaqing Zhang, Filip Bednar, Arvind Rao, Timothy Frankel, and Marina Pasca Di Magliano

Leveraging tissue-wide functional regulatory information improves portability of trans-ancestral polygenic risk score applications
Brad Crone and Alan Boyle

Mapping the complex genetic landscape of human neurons
Chen Sun, Kunal Kathuria, Sarah B Emery, ByungJun Kim, Ian E. Burbulis, Joo Heon Shin, Brain Somatic Mosaicism Network, Daniel R. Weinberger, John V. Moran, Jeffrey M. Kidd, Ryan E. Mills, and Michael J. McConnell

Mapping the molecular dependencies of combination therapeutic response to DNA damage response kinase inhibitors
Hanrui Zhang, Julian Kreis, Sven-Eric Schelhorn, Heike Dahmen, Thomas Grombacher, Michael Zühlsdorf, Frank T. Zenke, and Yuanfang Guan

Massively parallel reporter assay reveals promoter position- dependent and tissue-specific effects in islet TSSs
Maya Bose, Adelaide Tovar, Arushi Varshney, Yasuhiro Kyono, Jacob Kitzman, and Stephen CJ Parker

Modified profile-HMM for tandem repeat copy number determination in nanopore sequence reads
Kinsey Van Deynze, Camille Mumm, Jessica Switzenberg, Alexandra

Multiplexed enrichment of pharmacogene loci using Cas9-guided fragmentation-ligation to enable long read sequencing of native DNA
Monica Holmes, Alex Ade, Lars Fritsche, Qingzhi Liu, Veerabhadran Baladandayuthapani, and Brian Athey

Nuclear-cytoplasmic compartmentalization of cyclin B1-Cdk1 promotes robust timing of mitotic events
Gembu Maryu and Qiong Yang

OpenSRH: optimizing brain tumor surgery using intraoperative stimulated Raman histology
Cheng Jiang and Renly Hou

Opposing gradients of retinoic acid and sonic hedgehog specify tonotopic identity in the mouse cochlea
Shuze Wang, Saikat Chakraborty, Yujuan Fu, Mary Lee, Scott Jones, Jie Liu, and Jörg Waldhaus

Organ-specific prioritization of non-coding regulatory variants with stacking generalization
Nanxiang Zhao, Shengcheng Dong, and Alan P. Boyle

Predicting response to anti-disialoganglioside therapy in high risk neuroblastoma using fetal neuroendocrine development
Ryan Rebernick, Jae Eun Choi, and Marcin Cieslik

Protein-protein interaction network analysis through consensus prediction and virtual reality visualization
Eric W. Bell, Jacob H. Schwartz, and Peter L. Freddolino

Single cell tracking shows that integrated BMP signaling predicts fate in human pluripotent stem cells
Seth Teague, Gillian Primavera, Bohan Chen, Kyoung Jo, and Idse Heemskerk

Single-cell multi-omic velocity infers dynamic and decoupled gene regulation
Chen Li, Maria C. Virgilio, Kathleen L. Collins, and Joshua D. Welch

Status of the Human Proteome as of 2022
Gilbert S. Omenn, Lydie Lane, Christopher M Overall, Charles Pineau, Nicolle H. Packer, Ileana M. Cristea, Cecilia Lindskog, Susan T. Weintraub, Sandra Orchard, Michael H.A. Roehrl, Edouard Nice, Siqi Liu, Nuno Bandeira, Yu-Ju Chen, Tiannan Guo, Ruedi Aebersold, Robert L. Moritz, and Eric W. Deutsch

Translational applications of genome instability in lung adenocarcinoma and high-grade serous ovarian carcinoma
Noshad Hosseini and Marcin Cieslik

UINMF performs mosaic integration of single-cell multi-omic datasets using nonnegative matrix factorization
April R. Kriebel and Joshua D. Welch

Understanding caudal developmental abnormalities using single- nucleus multi-omics data from wild type and Danforth’s short tail mouse E9.5 tailbuds
Cynthia K Zajac, Ricardo D Albanus, Nandini Manickam, Vivek Rai, Erika Curka, Peedikayil Thomas, Catherine Keegan, and Stephen CJ Parker

Using massively parallel reporter assays to dissect context-specific gene regulation in T2D Adelaide
Tovar, Yasuhiro Kyono, Maya Bose, Kirsten Nishino, Arushi Varshney, Jacob Kitzman, and Stephen CJ Parker

VIGET: A web-based portal for vaccination response study based on Reactome pathways and ImmPort data
Tim Brunson, Nasim Sanati, Anthony Huffman, Anna Maria Masci, Jie Zheng, Patrick Conley, Oliver He, and Guanming Wu

Widespread age-associated changes in the chromatin architecture of skeletal muscle cell type populations
Keagan G Moo, Ricardo D’Oliveira Albanus, Arushi Varshney, Peter Orchard, Nandini Manickam, Markku Laakso, Jaakko Tuomilehto, Timo A. Lakka, Karen L. Mohlke, Michael Boehnke, Laura Scott, Heikki A. Koistinen, Francis S. Collins, and Stephen CJ Parker